RXDX-106 (CEP-40783)

Name	RXDX-106 (CEP-40783)
Synonyms	CS-2528 RXDX-106 CEP-40783 CEP 40783 RXDX-106 CEP40783 CEP-40783(RXDX-106) RXDX-106(CEP-40783) RXDX-106 (CEP-40783) 3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid [4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]amide 5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-
CAS	1437321-24-8

Molecular Formula	C31H26F2N4O6
Molar Mass	588.56
Density	1.394±0.06 g/cm3(Predicted)
pKa	10.42±0.70(Predicted)
Storage Condition	-20℃
In vitro study	RXDX-106 inhibits TAM and c-MET phosphorylation, accompanied by a decrease in downstream MAPK and PI3K signaling and cellular activity. In TAM-expressing cells, subnanomolar concentrations of RXDX-106 completely inhibited cell proliferation and cell viability.
In vivo study	RXDX-106 can inhibit tumors with activated TAM gene fusions and affect the TAM-expressing tumor microenvironment, thereby forming an overall anti-cancer environment.

Last Update：2024-01-02 23:10:35

biological activity	RXDX-106 (CEP-40783) is an orally available, effective, selective TAM(TYRO3, AXL, MER)/Met (c-Met) inhibitor had lower nanomolar biochemical activity in the peptide Phosphorylation Assay; there was a slow dissociation rate in the in vitro Kinase binding assay (T1/2 >120 min).
Target	Value
Axl (Cell-free assay)	7 nM
c-Met (Cell-free assay)	12 nM
Tyro3 (Cell-free assay)	19 nM 29 nM
MER (Cell-free assay)	29 nM
Use	a potent, selective and orally effective inhibitor of axl and c-Met with IC50 values of 7nm and 12nm, respectively.

Last Update：2024-04-10 22:29:15

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CAS: 1437321-24-8
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Product Name: RXDX-106 (CEP-40783) Visit Supplier Webpage Request for quotation
CAS: 1437321-24-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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RXDX-106 (CEP-40783)

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